PROSPECTUS SUPPLEMENT                                         File No. 333-38792
- ---------------------                                             Rule 424(b)(3)
(To Prospectus Supplement and Prospectus dated
June 16, 2000 and June 15, 2000, respectively)
Prospectus number:    2043


                            Merrill Lynch & Co., Inc.
                           Medium-Term Notes, Series B
                   Due Nine Months or More from Date of Issue


                               Floating Rate Notes


Principal Amount:  $10,000,000       Original Issue Date:      Nov. 14, 2000

CUSIP Number:      59018Y CN9        Stated Maturity Date:     Oct. 12, 2005

Interest Calculation:                 Day Count Convention:
- ---------------------                 ---------------------
|X|  Regular Floating Rate Note       |X|   Actual/360

|_|  Inverse Floating Rate Note       |_|   30/360

      (Fixed Interest Rate):          |_|   Actual/Actual


Interest Rate Basis:
- --------------------
|X|  LIBOR                            |_|   Commercial Paper Rate

|_|  CMT Rate                         |_|   Eleventh District Cost of Funds Rate

|_|  Prime Rate                       |_|   CD Rate

|_|  Federal Funds Rate               |_|   Other (see attached)

|_|  Treasury Rate
   Designated CMT Page:               Designated LIBOR Page:
        CMT Telerate Page:                  LIBOR Telerate Page:    3750
        CMT Reuters Page:                   LIBOR Reuters Page:


Index Maturity:            Three Months    Minimum Interest Rate: Not Applicable

Spread:                    +28 bps         Maximum Interest Rate: Not Applicable

Initial Interest Rate:     TBD             Spread Multiplier:     Not Applicable

Interest Reset Dates:      Quarterly,  on the 12th of every January, April, July
                           and October,  commencing January 12, 2001, subject to
                           modified following business day convention.

Interest Payment Dates:    Quarterly,  on the 12th of every January, April, July
                           and October,  commencing January 12, 2001, subject to
                           modified following business day convention.

Repayment at the
Option of the Holder:      The  Notes  cannot  be  repaid  prior  to the  Stated
                           Maturity Date.

Redemption at the
Option of the Company:     The Notes  cannot  be  redeemed  prior to the  Stated
                           Maturity Date.

Form:                      The  Notes  are  being  issued  in  fully  registered
                           book-entry form.

Trustee:                   The Chase Manhattan Bank

Dated:                     Nov. 7, 2000