Ownership Submission

FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

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3235-0104

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(Print or Type Responses)

1. Name and Address of Reporting Person ^*

Merrill Lynch Ventures LP 2001

2. Date of Event Requiring Statement (Month/Day/Year)
06/21/2004

3. Issuer Name and Ticker or Trading Symbol
SENOMYX INC [SNMX]

(Last)

(First)

(Middle)

4 WORLD FINANCIAL CENTER, 23RD FLOOR

4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

_____ Director	__X__ 10% Owner
_____ Officer (give title below)	_____ Other (specify below)

5. If Amendment, Date Original Filed(Month/Day/Year)

(Street)

NEW YORK, NY 10080

6. Individual or Joint/Group Filing(Check Applicable Line)
___ Form filed by One Reporting Person
_X_ Form filed by More than One Reporting Person

(City)

(State)

(Zip)

Table I - Non-Derivative Securities Beneficially Owned

1.Title of Security
(Instr. 4)

2. Amount of Securities Beneficially Owned
(Instr. 4)

3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)

4. Nature of Indirect Beneficial Ownership
(Instr. 5)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.			SEC 1473 (7-02)
	Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Series E Preferred	⁽¹⁾	⁽²⁾	Common Stock	3,448,394 ⁽³⁾	$ ⁽³⁾	D ⁽⁴⁾

Reporting Owners

Reporting Owner Name / Address	Relationships
Reporting Owner Name / Address	Director	10% Owner	Officer	Other
Merrill Lynch Ventures LP 2001 4 WORLD FINANCIAL CENTER, 23RD FLOOR NEW YORK, NY 10080		X
Merrill Lynch Group, Inc 4 WORLD FINANCIAL CENTER, 23RD FLOOR NEW YORK, NY 10080		X
MERRILL LYNCH & CO INC 4 WORLD FINANCIAL CENTER, 23RD FLOOR NEW YORK, NY 10080		X

Signatures

Frank Marinaro, VP, Merrill Lynch Ventures, LLC, its general partner		06/21/2004
^**Signature of Reporting Person		Date
Frank Marinaro, attorney in fact		06/21/2004
^**Signature of Reporting Person		Date
Frank Marinaro, attorney-in-fact		06/21/2004
^**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 5(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	Immed.
(2)	N/A
(3)	The number of shares listed in column 3 is the number of preferred shares held by the Reporting Person as of the date hereof. These shares are convertible at any time at the option of the holder, and will automatically convert upon the closing of the Issuer's initial public offering, in each case into the number of shares of common stock obtained by multiplying by the conversion rate listed in column 4 (.40798874).
(4)	The Reporting Person is a partnership of which Merrill Lynch Ventures, LLC is the general partner, which is a wholly owned subsidiary of Merrill Lynch Group, Inc., which is a wholly-owned subsidiary of Merrill Lynch & Co., Inc. Each of the reporting owners disclaims beneficial ownership of these securities.

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, See Instruction 6 for procedure.

Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB number.